Product Name: Tetracaine hydrochloride
Synonyms: Tetracaine HCL
storage temp: Refrigerator
Appearance: White Solid
Usage: Local anesthetic; Mainly used in mucosa anesthetic.The
function is stronger than Procaine and Lidocaine.
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The
ethyl ester is formed through an acid-catalyzed esterification
reaction. Base-catalyzed transesterification is achieved by boiling
the ethyl ester of 4-butylaminobenzoic acid with excess
2-dimethylaminoethanol in the presence of a small amount of sodium
Tetracaine (INN, also known as amethocaine; trade name Pontocaine.
Ametop and Dicaine) is a potent local anesthetic of the ester
group. It is mainly used topically in ophthalmology and as an
antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of
calcium release channels (ryanodine receptors) that control the
release of calcium from intracellular stores. Tetracaine is an
allosteric blocker of channel function. At low concentrations,
tetracaine causes an initial inhibition of spontaneous calcium
release events, while at high concentrations, tetracaine blocks
White or almost white crystalline powder
Matching with the working standard
A.By IR, To match with working standard
B: To 10ml of solution S add 1ml of ammonium thiocyanate solution
R.A white,crystalline precipitate is formed which,after
from water R and drying at 80ºC for 2h,melts at about 131ºC
C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to
dryness on a waterbath,allow to cool and dissolve the residue in
5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.
A violet colour develops
D. Solution S gives reaction of chlorides.
Conform to standard
Solution should be clear
Conform to standard
Loss on drying
Resiue on ignition
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