Prostaglandins Legal Anabolic Steroids Misoprostol High Purity CAS
CAS Number: 59122-46-2
Molecular Formula: C22H38O5
Molecular Weight: 382.60
Density: 1.078 g/cm3
Boiling Point: 497.3 ° C at 760 mmHg
Flash Point: 160.3 ° C
Solubility: Soluble to 100 mM in Ethanol
Appearance: White powder,Water-soluble, viscous liquid
PackAge: Aluminium foil bag packing
Storage: Keep in cool and dry place, away from light
Use: Prostaglandins;Pharmaceuticals;Prostanoid receptor and related
Misoprostol is approved for use in the prevention of NSAID-induced
gastric ulcers. It acts upon gastric parietal cells, inhibiting the
secretion of gastric acid by G-protein coupled receptor-mediated
inhibition of adenylate cyclase, which leads to decreased
intracellular cyclic AMP levels and decreased proton pump activity
at the apical surface of the parietal cell. Because other classes
of drugs, especially H2-receptor antagonists and proton pump
inhibitors, are more effective for the treatment of acute peptic
ulcers, misoprostol is only indicated for use by people who are
both taking NSAIDs and are at high risk for NSAID-induced ulcers,
including the elderly and people with ulcer complications.
Misoprostol is sometimes coprescribed with NSAIDs to prevent their
common adverse effect of gastric ulceration (e.g. with diclofenac
Misoprostol has other protective actions, but is only clinically
effective at doses high enough to reduce gastric acid secretion.
For instance, at lower doses, misoprostol may stimulate increased
secretion of the protective mucus that lines the gastrointestinal
tract and increase mucosal blood flow, thereby increasing mucosal
integrity. However, these effects are not pronounced enough to
warrant prescription of misoprostol at doses lower than those
needed to achieve gastric acid suppression.
However, even in the treatment of NSAID-induced ulcers, omeprazole
proved to be at least as effective as misoprostol,but was
significantly better tolerated, so misoprostol should not be
considered a first-line treatment. Misoprostol-induced diarrhea and
the need for multiple daily doses (typically four) are the main
issues impairing compliance with therapy.
The most commonly reported adverse effect of taking a misoprostol
orally for the prevention of stomach ulcers is diarrhea. In
clinical trials, an average 13% of patients reported diarrhea,
which was dose-related and usually developed early in the course of
therapy (after 13 days) and was usually self-limiting (often
resolving within 8 days), but sometimes (in 2% of patients)
required discontinuation of misoprostol.
The next most commonly reported adverse effects of taking
misoprostol orally for the prevention of gastric ulcers are:
abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting,
and constipation, but none of these adverse effects occurred
significantly more often than when taking placebos. In practice,
fever is almost universal when multiple doses are given every 4 to
Misoprostol should not be taken by pregnant women to reduce the
risk of NSAID-induced gastric ulcers because it increases uterine
tone and contractions in pregnancy, which may cause partial or
complete abortions, and because its use in pregnancy has been
associated with birth defects.
Misoprostol is a medication used to start labor, induce abortions,
prevent and treat stomach ulcers, and treat postpartum bleeding due
to insufficient contraction of the uterus. For abortions it is used
with mifepristone or methotrexate. It is a synthetic prostaglandin
Common side effects include diarrhea and abdominal pain. It is
pregnancy category X meaning that it is known to result in negative
fetal outcomes if taken during pregnancy. Uterine rupture may
It is on the World Health Organization's List of Essential
Medicines, the most important medications needed in a basic health
system. Misoprostol was invented and marketed by G.D. Searle &
Company under the trade name Cytotec, but other trade names and
generic formulations are available.
Biological Activity: Cytoprotective prostaglandin E 1 analog that
displays agonist activity at EP receptors. K i values are 120, 250,
67 and 67 nM at cloned mouse EP 1 , EP 2 , EP 3 and EP 4 receptors
respectively. Prevents NSAID-induced gastric ulceration. Use for
gastric and duodenal ulcers, hemorrhagic gastritis, acute gastric
mucosal lesions and other diseases.
The first chemical synthesis of prostaglandin E1 class anti-ulcer
drug, a strong inhibition of gastric acid secretion and prevent
ulcer formation, can inhibit gastric acid secretion and gastric
acid include basic due histamine pentagastrin, food or coffee
stimulation gastric acid secretion, but also to reduce gastric acid
secretion at night. It is the first clinical application of
anti-ulcer drugs. The extension of ulcer recurrence than violate
receptor antagonist, but the effect is less than relieve peptic
ulcer pain receptor antagonist island. For gastric and duodenal
ulcers, especially for cases of low levels of prostaglandins.
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